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Jamu is a product of natural ingredients, origin to Indonesia, which is used for health maintenance, disease treatment and prevention, the recovery of health, fitness, and beauty treatment.Treatment using herbs has been started by the ancestors of Indonesia. These natural ingredients are a legacy handed down by the ancestors of Indonesia, which has had knowledge of how to producethe natural herbs for medical, health care and beauty treatment. The purpose of this study was to determine the potential of herbal agro-industries in Sumenep, by using Exponential Comparative method and to determine the financial feasibility of herb agroindustries in Sumenep. Based on the results of this study, it showed that in the herbs agroindustry in Sumenep was ranked second leading commodity in Sumenep after cassava chips. Thus, which a very high internal rate of return (IRR) of 84.5%, it is recommended that the herbs agro-industry should be promoted and expended.